Imipramine for refractory daytime incontinence in the pediatric population

Two-thirds of children with refractory daytime incontinence experienced treatment response to imipramine, adding a valuable tool to the pediatric urologist's armamentarium in managing select, challenging patients.Table Pre- and post-Vancouver Symptom Scores (VSS) were statistically different in both complete and partial response groups.Pre-VSSPost-VSSpComplete response (n = 44)19.5 ± 3.69.5 ± 3.1<0.0001Partial response (n = 23)19.7 ± 4.313.5 ± 4.10.0002Non-responders (n = 16)19.4 ± 3.917.4 ± 3.90.92