Effect of multiple neonatal sevoflurane exposures on hippocampal apolipoprotein EÂ levels and learning and memory abilities

Multiple exposures to sevoflurane during the neonatal period decreased the volume of the hippocampus and increased the hippocampal expression of ApoE. The differential expression level of ApoE in different hippocampal subdivisions suggested that the expression of ApoE was regionally specific and reversible.