کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8837630 1612882 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of electrical stimulation of the infralimbic and prelimbic cortices on anxiolytic-like behavior of rats during the elevated plus-maze test, with particular reference to multiunit recording of the behavior-associated neural activity
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Effect of electrical stimulation of the infralimbic and prelimbic cortices on anxiolytic-like behavior of rats during the elevated plus-maze test, with particular reference to multiunit recording of the behavior-associated neural activity
چکیده انگلیسی
Fear and anxiety affect the activities of daily living and require concerted management, such as coping strategies, to preserve quality of life. The infralimbic (IL) and prelimbic (PL) medial prefrontal cortices have been implicated in the regulation of fear- and anxiety-like behavior, but their roles in overcoming fear- and anxiety-like behavior remain unknown. We investigated the anxiolytic-like effects of electrical stimulation of the IL and PL cortices in rats during the elevated plus-maze test. IL stimulation led to a significantly higher percentage of time spent and entries in the open arms, whereas PL stimulation did not have any significant behavioral effects. Subsequently, we recorded multiunit activity from the IL and PL cortices in rats using a wireless telemetry device, to determine whether activation of the IL occurs when rats enter the open arms in the elevated plus-maze test. The firing rate of IL neurons increased 1-3 s prior to entry from the closed arm to the open arm, whereas there were no corresponding changes in the firing rate of PL neurons. Taken together, the present findings suggest that the IL plays a key role in exerting active action to overcome anxiety-like behavior.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 353, 1 November 2018, Pages 168-175
نویسندگان
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