کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8838862 | 1613217 | 2018 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of pregabalin on brain edema, neurologic and histologic outcomes in experimental traumatic brain injury
ترجمه فارسی عنوان
اثرات پره گابالین بر ادم مغزی، نتایج نورولوژیک و بافت شناسی در آسیب مغزی آسیب دیده
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کلمات کلیدی
ICPTBIVCSVGCCsTraumatic brain injury - آسیب تروماتیک مغزSpinal cord injury - آسیب نخاعیBrain edema - ادم مغزیgamma amino butyric acid - اسید گاما آمینو بوتیریکCNS - دستگاه عصبی مرکزیBlood–brain barrier - سد خونی مغزیBBB - سد خونی مغزیcentral nervous system - سیستم عصبی مرکزیsci - علمیintracranial pressure - فشار درون جمجمهایneurological outcome - نتیجه عصبیPregabalin - پرگابالینvoltage-gated calcium channels - کانال های کلسیم با ولتاژGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
Brain edema and increased intracranial pressure (ICP) are among the main causes of neurological disturbance and mortality following traumatic brain injury (TBI). Since pregabalin neuroprotective effects have been shown, this study was performed to evaluate the possible neuroprotective effects of pregabalin in experimental TBI of male rats. Adult male Wistar rats were divided into 4 groups: sham, vehicle, pregabalin 30â¯mg/kg and pregabalin 60â¯mg/kg. TBI was induced in vehicle and pregabalin groups by Marmarou method. Pregabalin was administered 30â¯min after TBI. Sham and vehicle groups received saline. Brain water and Evans blue content and histopathological changes were evaluated 24, 5 and 24â¯h after TBI, respectively. The ICP and neurological outcomes (veterinary coma scale, VCS) were recorded before, 1â¯h and 24â¯h post TBI. The results showed a significant reduction in brain water content and ICP, and a significant increase in VCS of pregabalin group (60â¯mg/kg) as compared to vehicle group (Pâ¯<â¯0.05). Also, pregabalin reduced brain edema and apoptosis score as compared to vehicle group. Post TBI pregabalin administration revealed a delayed but significant improvement in ICP and neurological outcomes in experimental TBI. The underlying mechanism(s) was not determined and needs further investigation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 140, June 2018, Pages 169-175
Journal: Brain Research Bulletin - Volume 140, June 2018, Pages 169-175
نویسندگان
Manzumeh Shamsi Meymandi, Zahra Soltani, Gholamreza Sepehri, Sedigheh Amiresmaili, Fatemeh Farahani, Mohammadmehdi Moeini Aghtaei,