کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8839065 | 1613221 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Drugs targeting intermediate filaments can improve neurosupportive properties of astrocytes
ترجمه فارسی عنوان
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کلمات کلیدی
GFAPOGDglial fibrilary acidic proteinAstrocytes - آستروسیتEpoxomicin - اپوکسی مینیکOxidative stress - تنش اکسیداتیوCNS - دستگاه عصبی مرکزیcentral nervous system - سیستم عصبی مرکزیNeuroprotection - محافظت نورونی یا محافظت از عصبOxygen and glucose deprivation - محرومیت از اکسیژن و گلوکزOxygen-glucose deprivation - محرومیت گلوکز اکسیژنclomipramine - کلومیفامین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
In response to central nervous system (CNS) injury, astrocytes upregulate intermediate filament (nanofilament) proteins GFAP and vimentin. Whereas the intermediate filament upregulation in astrocytes is important for neuroprotection in the acute phase of injury, in some contexts it might inhibit some of the regenerative processes later on. Thus, timely modulation of the astrocyte intermediate filaments was proposed as a strategy to promote brain repair. We used clomipramine, epoxomicin and withaferin A, drugs reported to decrease the expression of GFAP, and assessed their effect on neurosupportive properties and resilience of astrocytes to oxygen and glucose deprivation (OGD). Clomipramine decreased protein levels of GFAP, as well as vimentin and nestin, and did not affect astrocyte resilience to oxidative stress. Withaferin A sensitized astrocytes to OGD. Both clomipramine and epoxomicin promoted the attachment and survival of neurons co-cultured with astrocytes under standard culture conditions. Moreover, epoxomicin increased neurosupportive properties of astrocytes after OGD. Our data point to clomipramine and epoxomicin as potential candidates for astrocyte modulation to improve outcome after CNS injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 136, January 2018, Pages 130-138
Journal: Brain Research Bulletin - Volume 136, January 2018, Pages 130-138
نویسندگان
Yolanda de Pablo, Meng Chen, Elin Möllerström, Marcela Pekna, Milos Pekny,