کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8839842 | 1613759 | 2018 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Uric acid and allopurinol aggravate absence epileptic activity in Wistar Albino Glaxo Rijswijk rats
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کلمات کلیدی
IL-1InosineCOX-1 and COX-2SWDA2ARIMPi.p.PGE2WAG/Rij - WAG / ردیفallopurinol - آلوپورینولUric acid - اسید اوریکElectroencephalogram - الکتروانسفالوگرافیIndomethacin - اندومتاسینinterleukin-1 - اینترلوکین-1spike-wave discharge - تخلیه موج سنبلهintraperitoneal - داخل صفاقیCNS - دستگاه عصبی مرکزیcentral nervous system - سیستم عصبی مرکزیAbsence epilepsy - صرع بدون وجودWAG/Rij rats - موش های WAG / RowInosine monophosphate - مونوفسفات inosineEEG - نوار مغزیProstaglandin E2 - پروستاگلاندین E2GABAAR - گابار
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Uric acid has a role in several physiological and pathophysiological processes. For example, uric acid may facilitate seizure generalization while reducing uric acid level may evoke anticonvulsant/antiepileptic effects. Allopurinol blocks the activity of xanthine oxidase, by which allopurinol inhibits catabolism of hypoxanthine to xanthine and uric acid and, as a consequence, decreases the level of uric acid. Although the modulation of serum uric acid level is a widely used strategy in the treatment of certain diseases, our knowledge regarding the effects of uric acid on epileptic activity is far from complete. Thus, the main aim of this study was the investigation of the effect of uric acid on absence epileptic seizures (spike-wave discharges: SWDs) in a model of human absence epilepsy, the Wistar Albino Glaxo/Rijswijk (WAG/Rij) rat. We investigated the influence of intraperitoneally (i.p.) injected uric acid (100â¯mg/kg and 200â¯mg/kg), allopurinol (50â¯mg/kg and 100â¯mg/kg), a cyclooxygenase 1 and 2 (COX-1 and COX-2) inhibitor indomethacin (10â¯mg/kg) and inosine (500â¯mg/kg) alone and the combined application of allopurinol (50â¯mg/kg) with uric acid (100â¯mg/kg) or inosine (500â¯mg/kg) as well as indomethacin (10â¯mg/kg) with uric acid (100â¯mg/kg) and inosine (500â¯mg/kg) with uric acid (100â¯mg/kg) on absence epileptic activity. We demonstrated that both uric acid and allopurinol alone significantly increased the number of SWDs whereas indomethacin abolished the uric acid-evoked increase in SWD number. Our results suggest that uric acid and allopurinol have proepileptic effects in WAG/Rij rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1686, 1 May 2018, Pages 1-9
Journal: Brain Research - Volume 1686, 1 May 2018, Pages 1-9
نویسندگان
Renáta Krisztina Lakatos, Árpád Dobolyi, Zsolt Kovács,