When “Extraneous” Becomes “Mine”. Neurophysiological Evidence of Sensorimotor Integration During Observation of Suboptimal Movement Patterns Performed by People with Multiple Sclerosis

Action observation is known to enhance sensorimotor system activation, and such effect has been linked to neural priming and response facilitation mechanisms. This facilitation effect, however, has been primarily studied by focusing on high-level motor proficiency, whereas evidence on the effect of observing poorly performed actions is still lacking. We then devised a study to investigate neural correlates of the observation of suboptimal motor acts as mirrored by corticospinal activation (via transcranial magnetic stimulation (TMS), Experiment 1) and by modulation of cortical oscillatory activity (via electroencephalography (EEG), Experiment 2). 40 participants were presented with four randomly reiterated videos. Videos depicted a healthy confederate, a minimally impaired multiple sclerosis (MS) patient, a mildly impaired MS patient, or a confederate trying to simulate mild motor difficulties performing a test concerning fine motor abilities. In Experiment 1 we analyzed TMS-induced motor-evoked potentials during the observation of videos. In Experiment 2 EEG data were analyzed in the frequency-domain. Analyses highlighted both increased corticospinal excitability and desynchronized alpha-beta oscillations during the observation of poorly performed motor acts performed by the mildly impaired MS patient. Further, we observed gradually increasing beta activity across videos reiterations, specifically for the minimally impaired patient's video. Reported findings corroborate the hypotheses that the action-observation network and the motor system might be involved in processes evoked in the attempt to understand and predict observed actions which do not belong to the onlookers' motor repertoire, reflecting in an increased sensorimotor activity.