کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8841417 | 1615018 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gender dependent contribution of muscarinic receptors in memory retrieval under sub-chronic stress
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Stress induces retrograde amnesia in humans and rodents. Muscarinic antagonism under normal physiological conditions causes gender dependent impairment in episodic memory retrieval. We aimed to explore the gender dependent role of muscarinic receptors in memory retrieval under sub-chronic stress condition. Male and female mice were trained for Morris water maze test and contextual fear conditioning, followed by 3â¯h restraint stress per day for five days. Stress was either given alone or in combination with a daily subcutaneous injection of scopolamine (1â¯mg/kg) or donepezil (1â¯mg/kg). Control mice were given saline without any stress. Sub-chronic stress (induced for five days) impaired spatial memory retrieval in males (Pâ¯<â¯0.005) but not in females (Pâ¯>â¯0.05). Stress induced spatial memory recall deficit in male mice was independent of muscarinic receptor activity (Pâ¯>â¯0.05). However, stress induced contextual fear memory recall impairment was reversed by donepezil treatment in male (Pâ¯<â¯0.005) and female (Pâ¯<â¯0.0001) mice. These findings suggest that differential role of muscarinic activity in retrieving different types of memories under stress depends on gender of subjects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 681, 10 August 2018, Pages 6-11
Journal: Neuroscience Letters - Volume 681, 10 August 2018, Pages 6-11
نویسندگان
Habiba Rashid, Touqeer Ahmed,