کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8841875 | 1615034 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Upregulation of BDNF and Interleukin-1Ã in rat spinal cord following noxious hind paw stimulation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of the present study was to investigate the protein levels of BDNF and IL-1Ã in the lumbar dorsal horn of the rat by Western blot analysis following a noxious thermal hind paw stimulation. Ten min, 1Â h and 3Â h after the combined chemical and thermal stimulation an up to 2-fold increase in BDNF and Il-1Ã protein expression was observed in the lumbar dorsal spinal cord. A pretreatment with the opioid analgesic morphine or the glial cell activation inhibitor minocycline partly attenuated protein expression. The present findings indicate that the BDNF and IL-1Ã induction within the dorsal horn may be linked to the development of hyperalgesia, and that opioid analgesics and probably inhibitors of glial cell activation can prevent sensitization in the pain pathway at spinal level.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 665, 5 February 2018, Pages 152-155
Journal: Neuroscience Letters - Volume 665, 5 February 2018, Pages 152-155
نویسندگان
Josef Donnerer, Ingrid Liebmann,