کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8842170 | 1615351 | 2018 | 122 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tyrosine hydroxylase as a sentinel for central and peripheral tissue responses in Parkinson's progression: Evidence from clinical studies and neurotoxin models
ترجمه فارسی عنوان
هیدروکسیاز تیروزین به عنوان یک نگهبان برای پاسخ های متابولیک مرکزی و محیطی در پیشرفت پارکینسون: شواهد حاصل از مطالعات بالینی و مدل های نوروکسین
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کلمات کلیدی
MPTPMAPKAPKmitogen-activated protein kinase-activated protein kinaseMSK1ENSMFBCDKpKaCaMKIIPP2AERK6-Hydroxydopamine6-OHDA1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine - 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridineCa2+/calmodulin-dependent protein kinase II - Ca2 + / calmodulin وابسته پروتئین کیناز IIl-DOPA - L-DOPAl-dihydroxyphenylalanine - L-دی هیدروکسی فنیل آلانینmedial forebrain bundle - بسته نرم افزاری پروبیالParkinson’s disease - بیماری پارکینسونCNS - دستگاه عصبی مرکزیGastrointestinal - دستگاه گوارشDopamine - دوپامینenteric nervous system - سیستم عصبی روده ایcentral nervous system - سیستم عصبی مرکزیextracellular signal regulated kinase - سیگنال خارج سلولی kinase را تنظیم می کندlocus coeruleus - لوکوس سیرولئوسPRAK - پراکاشprotein phosphatase 2A - پروتئین فسفاتاز 2Aprotein kinase A - پروتئین کیناز Aolfactory bulb - پیاز بویاییcatecholamine - کاتکولآمینهاcyclin-dependent kinase - کییناز وابسته به سیکلین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Parkinson's disease (PD) is a common neurodegenerative disease worldwide. While the typical motor symptoms of PD are well known, the lesser known non-motor symptoms can also greatly impact the patient's quality of life. These symptoms often appear before motor impairment, therefore identifying biomarkers that may predict PD risk or pathology has been a major and challenging endeavour. Given that the loss of dopamine, and its rate-limiting enzyme tyrosine hydroxylase (TH) occurs in PD, the expression and accompanying post-translational changes in TH during PD progression could yield insight into the disruption of cellular signalling occurring in the CNS, and also in peripheral tissues wherein catecholamine function plays a role. Furthermore, changes in expression and phosphorylation of TH in the brain and periphery can potentially reveal how TH stability and function are compromised in PD. As such, these changes can reveal how catecholamine synthesis capacity is gradually compromised and how changes in cellular signalling may govern the functional status of remaining catecholaminergic neurons. This review summarises the findings of clinical PD and neurotoxin models of PD that assessed TH expression or phosphorylation in catecholaminergic pathways in the brain and relevant peripheral tissues. We propose that establishing similar changes in TH expression and function in the CNS and periphery of established neurotoxin models can be a potential reference for comparison to changes in TH in human peripheral tissues. These changes in TH expression and phosphorylation may have predictive validity to estimate risk of PD progression before motor impairment is evident.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neurobiology - Volumes 165â167, JuneâAugust 2018, Pages 1-25
Journal: Progress in Neurobiology - Volumes 165â167, JuneâAugust 2018, Pages 1-25
نویسندگان
M.E. Johnson, M.F. Salvatore, S.A. Maiolo, L. Bobrovskaya,