کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8853731 | 1618906 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fenbuconazole exposure impacts the development of zebrafish embryos
ترجمه فارسی عنوان
قرار گرفتن در معرض فنبوکونازول بر روی رشد جنین های زرگری تاثیر می گذارد
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کلمات کلیدی
قارچ کش تریازول، ماهی، رشد جنین، مکانیسم،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
چکیده انگلیسی
Fenbuconazole (FBZ), a triazole-containing fungicide, is widely used in agriculture and horticulture. In the present study, the development and cardiac functioning were observed and determined in zebrafish embryos exposed to FBZ at 5, 50 and 500â¯ng/L nominal concentrations for 72â¯h. The results showed that 500â¯ng/L FBZ significantly increased pericardial edema rate, spine curvature rate, disturbed cardiac function, and led a shortened lower jaw. The transcription of genes such as tbx5, nkx2.5, tnnt2, gata4, bmp2b, myl7 was altered, which might be responsible for the cardiac developmental and functioning defects in the larvae. The deformation in bone development might be related with the impaired transcription levels of shh and bmp2b. The transcription of cyp26a1 (encoding retinoic acid metabolism enzyme) was significantly up-regulated in the 500â¯ng/L group, which might be a reason causing the teratogenic effect of FBZ. These results suggest that FBZ could have toxic effects on embryonic development, which should be considered in the risk evaluation of FBZ application.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 158, 30 August 2018, Pages 293-299
Journal: Ecotoxicology and Environmental Safety - Volume 158, 30 August 2018, Pages 293-299
نویسندگان
Yuqiong Wu, Qihong Yang, Meng Chen, Ying Zhang, Zhenghong Zuo, Chonggang Wang,