کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8854804 | 1618916 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Markers of genotoxicity and oxidative stress in farmers exposed to pesticides
ترجمه فارسی عنوان
نشانگرهای سمیت ژنتیکی و استرس اکسیداتیو در کشاورزان در معرض آفت کش ها
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
چکیده انگلیسی
The effects of chronic exposure to pesticides can lead to the development of several diseases, including different types of cancer, since the genotoxic and mutagenic capacity of these substances can be observed. The objective of this study is to investigate the relation between the occupational exposure to various pesticides and the presence of DNA damage and oxidative stress. Blood samples from 50 rural workers (41 men and 9 women) exposed to pesticides, 46 controls (20 men and 26 women) from the same city (Antônio Carlos, Santa Catarina state, Brazil) and 29 controls (15 men and 14 women) from another city (Florianópolis, Santa Catarina state, Brazil), were evaluated using the comet assay and the cytokinesis-block micronucleus (CBMN) technique for genetic damage, and the test of thiobarbituric acid reactive substances (TBARS) and catalase (CAT) activity for the oxidative stress. Cholinesterase activities were also determined, but there was no statistical difference among exposed workers and controls. Significant differences were found in DNA damage among groups. The comet assay performed on peripheral blood lymphocytes of these individuals had a significantly higher DNA damage index in the exposed group comparing to controls (p < 0.0001). MNi (p < 0.001), NBUDs (p < 0.005) and NPBs (p < 0.0001) were also found to be significantly higher in the exposed group. The TBARS values were significantly higher comparing to the Florianopolis control group (p < 0.0001). Even though CAT values were higher than controls, there was no statistical difference. Thus, it is concluded that the exposed individuals, participants of this study, are more subject to suffer genetic damage and, consequently, more susceptible to diseases resulting from such damages.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 148, February 2018, Pages 177-183
Journal: Ecotoxicology and Environmental Safety - Volume 148, February 2018, Pages 177-183
نویسندگان
Carolina Hilgert Jacobsen-Pereira, Claudia Regina dos Santos, Flora Troina Maraslis, Luisi Pimentel, Ana Júlia Lobo Feijó, Clarice Iomara Silva, Guilherme da Silva de Medeiros, Rodrigo Costa Zeferino, Rozangela Curi Pedrosa, Sharbel Weidner Maluf,