کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8855057 | 1619011 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fine particulate matter constituents and stress hormones in the hypothalamus-pituitary-adrenal axis
ترجمه فارسی عنوان
اجزای ذرات جامد و هورمون استرس در محور هیپوتالاموس-هیپوفیز-آدرنال
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
چکیده انگلیسی
Fine particulate matter (PM2.5) has recently been associated with the activation of the hypothalamus-pituitary-adrenal (HPA) axis, increasing cardiometabolic risks. However, it is unknown which constituents of PM2.5 were mainly responsible for these associations. In a longitudinal panel study with 4 repeated measurements among 43 college students in Shanghai, China, we measured serum levels of corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and cortisol, as indicators of HPA axis activation. Then, we evaluated the associations of 22 constituents of PM2.5 with these stress hormones using linear mixed-effect models. During the study period, the average daily concentration of PM2.5 was 41.1â¯Î¼g/m3. We found that short-term exposure to PM2.5 was associated with elevated levels of the 3 stress hormones. We observed that water-soluble inorganic ions, especially nitrate (NO3â) and ammonium, had stronger influences on 3 hormones. Six metallic elements, including Zn, Mn, Cu, Fe, Br, and Cr, had positive but generally instable associations with 3 hormones. The effects of organic carbon and elemental carbon on hormones were generally weak. When correcting for multiple comparisons using false discovery rate, NO3â was still significantly associated with CRH, but other important associations turned to be insignificant. An interquartile range increase in NO3â on the previous day were associated with 12.13% increase (95% confidence interval: 4.45%, 20.37%) in CRH. Our findings suggested that water-soluble inorganic constituents of PM2.5 (especially, NO3â) might have stronger influences on the activation of HPA axis than carbonaceous and elemental components.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environment International - Volume 119, October 2018, Pages 186-192
Journal: Environment International - Volume 119, October 2018, Pages 186-192
نویسندگان
Yue Niu, Renjie Chen, Yongjie Xia, Jing Cai, Zhekang Ying, Zhijing Lin, Cong Liu, Chen Chen, Li Peng, Zhuohui Zhao, Wenhao Zhou, Jianmin Chen, Dongfang Wang, Juntao Huo, Xinning Wang, Qingyan Fu, Haidong Kan,