Reversal of deltamethrin-induced oxidative damage in rat neural tissues by turmeric-diet: Fourier transform-infrared and biochemical investigation

The present study is designed to determine the protective effect of turmeric (TMR) against neural oxidative damage caused by deltamethrin (DLM). Here we have employed mainly Fourier transform-infrared (FT-IR) spectroscopy to understand this event, in addition to biochemical analysis. For this purpose, rats were randomly divided into four groups (n = 6); control, TMR (1% turmeric-diet), DLM-treated (41 ppm) and TMR co-administrated with DLM for 48 days. The FT-IR spectra of brain tissues reflect the significant changes in the area values of macromolecules including proteins, lipids and nucleic acids in DLM-treated rats compared to control. In addition, DLM caused increase in the malondialdehyde (MDA) level accompanied by decrease in antioxidant enzymes activity such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR). However, the TMR co-administered with DLM group, exhibits appreciable restoration in area values and peaks of IR spectra and also the restoration of the mentioned antioxidant enzyme activities. The group merely fed with TMR showed insignificant changes in all investigated parameters. Therefore, the results reveal that, 1% of turmeric has a protective effect against deltamethrin caused neural oxidative damage.