کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8899789 | 1631549 | 2018 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stability and existence results for a time-delayed nonlocal model of hematopoietic stem cells dynamics
ترجمه فارسی عنوان
نتایج پایداری و وجود یک مدل غیرخطی تاخیر زمانی از دینامیک سلولهای بنیادی خونساز
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موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
آنالیز ریاضی
چکیده انگلیسی
In this paper, we consider a time-delayed nonlocal model describing the dynamics of hematopoietic stem cells (HSCs), which represent the immature cells in the hematopoiesis process. By the method of characteristics, the nonlocal model is obtained from an age-structured reaction-diffusion system in bounded domain with Dirichlet boundary conditions. Along this paper, we focus on the mathematical analysis of it. Firstly, we give some results on the existence, uniqueness, positivity and boundedness of solutions. Next, we obtain a threshold value Rs and prove that the trivial steady state is globally asymptotically stable when Rs<1. When Rs>1, we prove the existence and uniqueness of positive stationary solution under the respective additional conditions on the monotonicity and non-monotonicity of the integral term. Finally, we prove the uniform weak persistence of the system when Rs>1. Some numerical simulations are provided to verify the validity of our theoretical results.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Mathematical Analysis and Applications - Volume 463, Issue 2, 15 July 2018, Pages 1147-1168
Journal: Journal of Mathematical Analysis and Applications - Volume 463, Issue 2, 15 July 2018, Pages 1147-1168
نویسندگان
Abdennasser Chekroun, Toshikazu Kuniya,