کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8918037 1642814 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New opportunities for optimal design of dynamic experiments in systems and synthetic biology
ترجمه فارسی عنوان
فرصت های جدید برای طراحی بهینه از آزمایشات پویا در سیستم و زیست شناسی مصنوعی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر علوم کامپیوتر (عمومی)
چکیده انگلیسی
Recently developed dynamic experimental techniques offer new opportunities for the use of model-based experimental design in the construction and refinement of predictive models of cellular behaviour. Specifically, novel optogenetic and microfluidic tools have been made accessible by the distribution of low-cost, automated hardware designs that rely on readily available components and inexpensive construction processes. Experimental design methods can be applied to these platforms to identify time-varying input signals that generate maximally informative system responses. We review these developments and illustrate how the convergence of these approaches facilitates the construction of accurate biological models of both natural and engineered cellular systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Systems Biology - Volume 9, June 2018, Pages 42-48
نویسندگان
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