کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8918974 1642864 2018 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The future of traction force microscopy
ترجمه فارسی عنوان
آینده میکروسکوپ نیروی کشش
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی
Animal cells continuously sense and respond to mechanical force. Quantifying these forces remains a major challenge in bioengineering; yet such measurements are essential for the understanding of cellular function. Traction force microscopy is one of the most successful and broadly-used force probing technologies, chosen for the simplicity of its implementation, flexibility to mimic cellular conditions, and well-established analysis pipe-line. Here, we review the accomplishments, and discuss the applicability and limitations of traction force microscopy. We explain fundamental shortcomings of the method, summarise latest improvements, and outline future pathways towards the impact of the method, especially considering latest developments in state-of-the-art super-resolution fluorescence imaging. In light of the increasing discovery of the importance of mechanobiology in cell physiology, we envisage traction force microscopy to remain a major player for quantifying mechanical forces in living cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Biomedical Engineering - Volume 5, March 2018, Pages 1-5
نویسندگان
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