کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8919062 | 1642868 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immune engineering: From systems immunology to engineering immunity
ترجمه فارسی عنوان
مهندسی ایمنی: از سیستم ایمنی به ایمنی مهندسی
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کلمات کلیدی
ایمونولوژی سیستم، توالی انتخاب رشته ایمنی، درمانی سلول اتخاذ شده، مانع بازرسی ایمن مهندسی ایمنی،
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
چکیده انگلیسی
The smallpox vaccine represents the earliest attempt in engineering immunity. The recent success of chimeric antigen receptor T cells (CAR-T cells) in cancer once again demonstrates the clinical potential of immune engineering. Inspired by this success, diverse approaches have been used to boost various aspects of immunity: engineering dendritic cells (DCs), natural killer (NK) cells, T cells, antibodies, cytokines, small peptides, and others. With recent development of various high-throughput technologies (of which engineers, especially biomedical engineers/bioengineers contributed significantly), such as immune repertoire sequencing, and analytical methods, a systems level of understanding immunity (or the lack of it) beyond model animals has provided critical insights into the human immune system. This review focuses on recent progressed made in systems biology and the engineering of adaptive immunity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Biomedical Engineering - Volume 1, March 2017, Pages 54-62
Journal: Current Opinion in Biomedical Engineering - Volume 1, March 2017, Pages 54-62
نویسندگان
Ning Jiang,