کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8925930 | 1643641 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Long non-coding RNA in liver metabolism and disease: Current status
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کبدشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Long non-coding RNA in liver metabolism and disease: Current status Long non-coding RNA in liver metabolism and disease: Current status](/preview/png/8925930.png)
چکیده انگلیسی
Long non-coding RNAs (lncRNAs) are comprised of RNA transcripts exceeding 200 nucleotides in length but lacking identifiable open reading frames (with rare exceptions). Herein, we highlight emerging evidence demonstrating that lncRNAs are critical regulators of liver metabolic function and diseases. We summarize current knowledges about dysregulated lncRNAs and outline the underlying molecular mechanisms by which lncRNAs control hepatic lipid ad glucose metabolism, as well as cholestatic liver disease. Liver-specific triglyceride regulator (lncLSTR), Lnc18q22.2, steroid RNA activator (SRA), highly upregulated in liver cancer (HULC), metastasis associated in lung adenocarcinoma transcript 1 (MALAT1), liver glucokinase repressor (lncLGR), maternally expressed gene 3 (MEG3), and H19, lncHR1, lnc-HC, apolipoprotein A1 antisense transcript (APOA1-AS), DYNLRB2-2, and LXR-induced sequence (LeXis) are included in the discussion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Liver Research - Volume 1, Issue 3, September 2017, Pages 163-167
Journal: Liver Research - Volume 1, Issue 3, September 2017, Pages 163-167
نویسندگان
Yulan Zhao, Jianguo Wu, Suthat Liangpunsakul, Li Wang,