کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8942680 | 1645111 | 2018 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ultrasound-assisted dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry for determination of parabens in human breast tumor and peripheral adipose tissue
ترجمه فارسی عنوان
میکروکساکتیو مایع مایع مایع مایع با استفاده از سونوگرافی و سپس طیف سنجی جرم کروماتوگرافی گاز برای تعیین پارابنها در تومور سینه انسان و بافت چربی محیطی
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
An efficient method for the determination of eight parabens in human breast tumor (nâ¯=â¯102) and peripheral adipose tissue samples (nâ¯=â¯87) was successfully developed. After a precipitation procedure (acetonitrile-water-15% (w/v) zinc sulfate solution) was applied to finely-chopped tissue samples, ultrasound-assisted dispersive liquid-liquid microextraction was conducted on the sample solution. The extracted parabens were determined by gas chromatography-mass spectrometry. Significant factors influencing extraction efficiency were screened and optimized using Plackett-Burman design and central composite design. The optimized conditions were obtained at 93â¯Î¼L 1âdecanol, 500â¯Î¼L methanol, and ultrasound irradiation power 156â¯W for 44â¯s. Under the optimum condition, the proposed method showed enrichment factors between 44.9 and 60.5. The detection limits for parabens were between 0.5 and 1.0â¯ngâ¯gâ1. Calibration curves showed good linearity with coefficients of determination higher than 0.993. Relative standard deviations were lower than 11.8%. No significant matrix effects were observed as recoveries from spiked tissue samples ranged between 79.6% and 113.6%. The sample pretreatment procedure and analytical characteristics showed comparable or superior to those of the previously reported methods. Finally, the procedure was successfully employed in real samples and results indicated a wide existence of parabens in the tested tissues. At least one paraben was detected in 98.9% tissues and the levels ranged from 0.5 to 5931.1â¯ngâ¯gâ1, depending on the types of analytes and tissues.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 1096, 1 October 2018, Pages 48-55
Journal: Journal of Chromatography B - Volume 1096, 1 October 2018, Pages 48-55
نویسندگان
Xiong Shen, Jian Liang, Luxia Zheng, Hong Wang, Zi Wang, Qiuyi Ji, Qiaoli Chen, Qianzhou Lv,