کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8943742 1645202 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, characterization, and evaluation of antifungal and antioxidant properties of cationic chitosan derivative via azide-alkyne click reaction
ترجمه فارسی عنوان
سنتز، خصوصیات و ارزیابی خواص ضد قارچی و آنتی اکسیدانی مشتق شده از کیتیون کیتوزان با استفاده از واکنش کلیک روی آیزید آلکین
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
In this work, quaternary ammonium group was introduced into chitosan backbone by cuprous-catalyzed azide-alkyne cycloaddition (CuAAC) to synthesize the cationic chitosan derivative bearing 1,2,3-triazole. The products were identified structurally by FTIR, 1H NMR spectroscopy, XRD, and elemental analysis. The water solubility of chitosan derivatives at different pH values was determined by a turbidity measurement. The antifungal properties of cationic chitosan derivatives against Botryis cinerea, Phomopsis asparagi, Fusarium oxysporum f. sp. niveum, and Fusarium oxysporum f. sp. cucumerium were evaluated using the radial growth assay. Besides, the antioxidant activities of them were also tested by superoxide-radical scavenging and reducing power assays. Compared to chitosan, cationic chitosan derivative bearing 1,2,3-triazole showed the good water solubility especially at alkaline condition, excellent antifungal action with over 70% inhibitory indices against tested fungi at 1.0 mg/mL, and enhanced antioxidant activity with complete scavenging efficiency against superoxide-radical at 1.6 mg/mL because of the introduction of 1,2,3-triazole and quaternary ammonium moieties. These excellent biological properties present a promising prospect for this chitosan derivative in antifungal and antioxidant biomaterials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 120, Part A, December 2018, Pages 318-324
نویسندگان
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