Mendelian randomization: Its impact on cardiovascular disease

Discoveries of rare variants in Mendelian disorders resulted in the successful development of drugs for the general population. An MRS may also predict the pharmacological effectiveness and adverse side effects of novel drugs targeting specific molecules. An MRS could become a standard process to be performed before the development of novel drugs. Furthermore, future guidelines for the prevention of CAD should consider the genetic information of individuals, which will result in precision medicine for cardiovascular diseases.