Le syndrome cardio-rénal

The term “cardio-renal syndrome” is defined as any cardiac and renal disorder by which acute or chronic dysfunction in one organ may induce acute or chronic dysfunction in the other. Five subtypes have been described. There are acute and chronic cardio-renal syndromes (CRS type 1 and 2 respectively) and acute and chronic reno-cardiac syndromes (CRS type 3 and 4 respectively); CRS type 5 is characterised by the association of renal failure and cardiac failure secondary to acute or chronic systemic pathology. The diagnosis of these syndromes is based both on the clinical evaluation of patients and on the measurement of specific biomarkers of cardiac dysfunction (natriuretic peptides in particular) and renal dysfunction (creatinine in the first place but also NGAL, cystatin C, KIM-1). The management of these syndromes depends first and foremost on the etiological management of the cardiac or renal dysfunction at the origin of the syndrome. It is associated with the prevention of factors that can worsen both heart disease and kidney disease.