کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8950936 | 1645799 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The β2-adrenergic receptor is involved in differences in the protein degradation level of the pectoral muscle between fast- and slow-growing chicks during the neonatal period
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کلمات کلیدی
GAPDHIGF-IMuscle atrophy F-box3-Methylhistidine - 3-متیل هیستیدینProtein degradation - تخریب پروتئینforkhead Box O - جعبه O جعبه OInsulin-like growth factor-I - عامل رشد انسولین مانند ISkeletal muscle - عضله اسکلتیFoxO - فاکسوChicken - مُرغ خانگیglyceraldehyde-3-phosphate dehydrogenase - گلیسرالیدید-3-فسفات دهیدروژنازβ2-adrenergic receptor - گیرنده β2-adrenergicadrenergic receptor - گیرنده آدرنرژیکUbiquitin - یوبیکویتین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of this study was to investigate whether β2-AR mRNA expression is involved in either atrogin-1/MAFbx mRNA expression or protein degradation in chicken skeletal muscle by comparing fast- and slow-growing chicks during the neonatal period. Based on their body weight gain from 1 to 5â¯days of age, 5-day-old chicks (Gallus gallus domestics) were divided into a slow-growing and a fast-growing group, the mean weight gains of which were 6.3â¯Â±â¯1.3â¯g/day and 11.3â¯Â±â¯0.9â¯g/day, respectively. The ratio of pectoral muscle weight to total body weight was higher in the fast-growing group of chicks than in the slow-growing group. In addition, the plasma 3-methylhistidine concentration, an index of protein degradation in skeletal muscle, was significantly lower in the fast-growing than in the slow-growing chicks. The mRNA expression of β2-AR, which we previously found is involved in decreasing muscle protein degradation by suppression atrogin-1/MAFbx mRNA expression, was significantly higher in the pectoral muscle of the fast-growing group compared with that of the slow-growing group. Concordantly, lower mRNA expression of atrogin-1/MAFbx was observed in the pectoral muscle of the fast-growing chicks. However, in the sartorius muscle, which is a muscle in the thigh, the ratio of the muscle weight to total body weight was not significantly different between the two groups of chicks at 5â¯days of age. In addition, there was no significant difference in the mRNA expressions of β2-AR and atrogin-1/MAFbx in the sartorius muscle between these two groups. These results suggest that β2-AR expression levels might be physiologically significant in the control of protein degradation in the pectoral muscle of neonatal chicks.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 267, 1 October 2018, Pages 45-50
Journal: General and Comparative Endocrinology - Volume 267, 1 October 2018, Pages 45-50
نویسندگان
Saki Shimamoto, Daichi Ijiri, Kazuki Nakashima, Mana Kawaguchi, Akira Ohtsuka,