کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8956960 1646187 2018 27 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inflammatory and metabolic mechanisms underlying the calcific aortic valve disease
ترجمه فارسی عنوان
مکانیزم های التهابی و متابولیک تحت تأثیر بیماری دریچه آئورت کلسیفیک
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
Calcific aortic valve disease (CAVD) is no longer considered a simple passive process of calcium deposition that occurs with advanced age. Biomineralization in CAVD is a complex, regulated process that involves valvular, circulating, bone marrow-derived cells, macrophage heterogeneity and genetic factors along with biochemical and mechanical factors. The current review will discuss the recently discovered important role of inflammation, metabolic risk factors, and molecular and cellular mechanisms that promote CAVD, as well as the link between osteogenic signals in the skeletal and cardiovascular systems. This may inform future therapeutic strategies for CAVD progression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 277, October 2018, Pages 60-65
نویسندگان
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