کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8962606 | 1646587 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Recherche de la mutation T790Â MÂ : savoir persévérer
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In cases of advanced EGFR mutation-positive non-small cell lung cancer, first or second generation EGFR-tyrosine kinase inhibitors (TKI-EGFR 1G or TKI-EGFR 2G) are recommended as first line treatment. Inexorably, progressive disease occurs and, in 50-60% of the cases, is secondary to a T790Â M resistant mutation. The prescription of osimertinib (TKI-EGFR3G) in second line is dependent on identification of the T790Â M mutation. We report 7 cases in which the identification of the T790Â M mutation required repeated analyses of cell free DNA and/or biopsies over a period of time. In some cases, a positive result was obtained a long time after progressive disease had been diagnosed during treatment with first or second generation EGFR-TKI. We discuss here the different modalities of screening for the T790Â M mutation and we encourage persevering in this search when no alternative mechanism of resistance has been identified.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revue des Maladies Respiratoires - Volume 35, Issue 7, September 2018, Pages 731-737
Journal: Revue des Maladies Respiratoires - Volume 35, Issue 7, September 2018, Pages 731-737
نویسندگان
H. Bourien, A. Lespagnol, A. Prigent, G. Leveiller, H. Lena, C. Ricordel, R. Corre,