کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8978206 | 1106585 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The two Cg-timp mRNAs expressed in oyster hemocytes are generated by two gene families and differentially expressed during ontogenesis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The two Cg-timp mRNAs expressed in oyster hemocytes are generated by two gene families and differentially expressed during ontogenesis The two Cg-timp mRNAs expressed in oyster hemocytes are generated by two gene families and differentially expressed during ontogenesis](/preview/png/8978206.png)
چکیده انگلیسی
We previously characterized a Crassostrea gigas tissue inhibitor of metalloproteinase (Cg-timp 1.3) with potential role in wound healing and defense mechanisms. Here we isolated a second cDNA (Cg-timp 1.1) encoding a protein that contains the characteristic signature of TIMP proteins. Sequence analysis of the two transcripts showed that they originate from two distinct genes. The two proteins, Cg-TIMP 1.1 and 1.3, are closely related and share 81% identity. Northern blot analysis of Cg-timp gene expression in adult oyster hemocytes indicated that the ratio between the two transcripts was constant from one oyster to another (Cg-timp 1.1 and 1.3 represent 32 and 68%, respectively). Conversely, during ontogenesis the expression pattern of the two Cg-timp genes was different. Indeed, Cg-timp 1.3 mRNAs were detected from the larval D stage whereas Cg-timp 1.1 transcripts were undetectable up to 22 days post-fertilization. The difference in expression pattern of the two Cg-timp genes may reveal distinct implications of these genes in the embryos and larvae developments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 29, Issue 10, 2005, Pages 831-839
Journal: Developmental & Comparative Immunology - Volume 29, Issue 10, 2005, Pages 831-839
نویسندگان
Caroline Montagnani, Ana Tirape, Viviane Boulo, Jean-Michel Escoubas,