کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8980745 1107735 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protein Expression of Mdm2 and p53 in Hyperplastic and Neoplastic Lesions of the Canine Circumanal Gland
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Protein Expression of Mdm2 and p53 in Hyperplastic and Neoplastic Lesions of the Canine Circumanal Gland
چکیده انگلیسی
Hyperplastic and neoplastic lesions of the circumanal gland in dogs were examined immunohistochemically for nuclear expression of Mdm2 and p53 proteins. Mdm2 nuclear labelling was detected in 64.3% of hyperplastic lesions and 70.7% of adenomas, the immunolabelling being stronger in the latter. Mdm2 reactivity in reserve-like cells in adenomas showed wide variation, the immunoreactive cells ranging from 4 to 80%. No reactivity was shown in 81.9% of adenocarcinomas. In contrast to Mdm2 reactivity, each of 14 hyperplastic lesions and 11 adenocarcinomas, and 60 of 65 adenomas (92.3%) failed to show nuclear p53 reactivity. These results suggest that increased expression of Mdm2 is an early event in circumanal gland tumorigenesis, and may be present in the absence of nuclear p53 protein accumulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Comparative Pathology - Volume 132, Issue 1, January 2005, Pages 27-32
نویسندگان
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