کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8980774 | 1107743 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evolution of T Lymphocytes and Cytokine Expression in Classical Swine Fever (CSF) Virus Infection
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Evolution of T Lymphocytes and Cytokine Expression in Classical Swine Fever (CSF) Virus Infection Evolution of T Lymphocytes and Cytokine Expression in Classical Swine Fever (CSF) Virus Infection](/preview/png/8980774.png)
چکیده انگلیسی
This study characterized the cell-mediated immune response in pigs inoculated with the Alfort 187 isolate of classical swine fever (CSF) virus. Quantitative changes in the T-lymphocyte population (CD3+, CD4+ and CD8+) and qualitative changes in cytokine expression (IL-2, IL-4 and IFNγ) by these cells in serum, thymus and spleen were demonstrated. These changes coincided spatially and temporally with previously described quantitative and qualitative changes in monocyte-macrophage populations, thus demonstrating the contribution of the two cell populations to lymphoid depletion. Moreover, examination of cytokine expression in thymus and spleen samples revealed a type 1 cell-mediated immune response in the early and middle stages of the experiment, giving way to a type 2 immune response towards the end of the experiment; these findings, which accorded with the serological results and lymphopenia, may influence the delayed humoral response characteristic of CSF.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Comparative Pathology - Volume 132, Issue 4, May 2005, Pages 249-260
Journal: Journal of Comparative Pathology - Volume 132, Issue 4, May 2005, Pages 249-260
نویسندگان
P.J. Sánchez-Cordón, A. Núñez, F.J. Salguero, L. Carrasco, J.C. Gómez-Villamandos,