کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8991256 | 1555811 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Infectivity of a novel type of Cryptosporidium andersoni to laboratory mice
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Infectivity of a novel type of Cryptosporidium andersoni to laboratory mice Infectivity of a novel type of Cryptosporidium andersoni to laboratory mice](/preview/png/8991256.png)
چکیده انگلیسی
Previously, we reported 'a novel type' of Cryptosporidium andersoni detected from cattle in Japan, and showed that the isolate was infective to mice. In the present study, we examined the patterns of oocyst shedding in both immunocompromised and immunocompetent mice, as well as pathological lesions in the infected mice. After oral inoculation with 1Â ÃÂ 106 oocysts, all five severe combined immunodeficiency (SCID) mice began to shed endogenously produced oocysts on day 6 post-inoculation (p.i.). The number of oocysts per day (OPD) reached 1Â ÃÂ 106 on day 17 p.i., and an OPD level of 1Â ÃÂ 106 to 107 was maintained until 91 days p.i. when the mice were sacrificed. In the five immunocompetent mice inoculated with 1Â ÃÂ 106 oocysts, the pre-patent and patent periods were 6 and 19 days, respectively, and the maximal OPD level was 1.5Â ÃÂ 105 on average. On histological examinations of infected SCID mice, a large number of parasites were present on the surface of the gastric glands of the stomach, but not in other organs examined. In conclusion, the novel type of C. andersoni, which genetically coincides with C. andersoni reported in other countries, is infective to mice, but susceptibility was lower than that of Cryptosporidium muris infecting rodents from the perspective of infectivity to immunocompetent mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Parasitology - Volume 129, Issues 1â2, 20 April 2005, Pages 165-168
Journal: Veterinary Parasitology - Volume 129, Issues 1â2, 20 April 2005, Pages 165-168
نویسندگان
Makoto Matsubayashi, Isao Kimata, Motohiro Iseki, Tomoya Hajiri, Hiroyuki Tani, Kazumi Sasai, Eiichiroh Baba,