Evaluation of Bayesian Predictability of Vancomycin Concentration Using Population Pharmacokinetic Parameters in Pediatric Patients

A theoretical approach using a simulation technique was also examined to evaluate the predictive performance. The results suggested that the predictability at the peak was not necessarily good at all sampling times and the predictability at the trough was better when a later time point was used. The optimal sampling time for prediction of VCM concentration in pediatric patients is discussed.