Differential pulse voltammetric determination of carvedilol in tablets dosage form using glassy carbon electrode

The electrochemical oxidation of antihypertensive drug carvedilol has been studied in pH range 2.0-11.0 at a glassy carbon electrode by cyclic and differential pulse voltammetry. Two oxidation processes were produced in different supporting electrolyte media. Both oxidation processes were irreversible and diffusion-controlled. The first oxidation process was chosen for the analysis of carvedilol. A very resolved voltammetric peak was obtained in Britton-Robinson buffer at pH 8.0 using differential pulse mode. The linear response was obtained in the range of 0.25-10.00 μg ml-1. The limit of detection was found to be 0.10 μg ml-1. The developed method was used for the determination of carvedilol in tablet dosage form.