کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9007878 | 1122720 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective effects of a Traditional Chinese Medicine, You-Gui-Wan, on steroid-induced inhibition of cytokine production in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Protective effects of a Traditional Chinese Medicine, You-Gui-Wan, on steroid-induced inhibition of cytokine production in mice Protective effects of a Traditional Chinese Medicine, You-Gui-Wan, on steroid-induced inhibition of cytokine production in mice](/preview/png/9007878.png)
چکیده انگلیسی
You-Gui-Wan (YGW), a classical yang-tonic prescription of Traditional Chinese Medicine (TCM), is thought to boost the body function against diseases. To determine the effects of YGW on the steroid-induced inhibition of cytokine production in mice, we established a murine model with hydrocoticoid (HC)-induced cytokine suppression. The results showed that oral administration of YGW protected mice against HC-induced inhibition of IFN-γ, IL-2, IL-4 and IL-10 transcription, and the percentages of CD4+ and CD8+ T cells containing intracellular cytokines including IFN-γ, IL-4 and IL-10 were significantly increased in murine spleen. The protection of YGW against HC-induced inhibition of cytokine production was further confirmed by the elevated serum level of IFN-γ in YGW-treated mice. The results suggest that YGW improve the immune function even in the serious immunosuppressive condition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 5, Issue 6, June 2005, Pages 1041-1048
Journal: International Immunopharmacology - Volume 5, Issue 6, June 2005, Pages 1041-1048
نویسندگان
Chengfang Yao, Li Wang, Shengye Cai, Haiming Wei, Xianbin Zhou, Hengxiao Wang, Zhigang Tian,