کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9008018 | 1122731 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bee venom modulates murine Th1/Th2 lineage development
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Administration of bee venom (BV) elicits anti-inflammatory, anti-nociceptive and anti-allergic effects in various animal models. This study was designed to evaluate the direct effects of BV on helper T cell activities and on Th1/Th2 lineage development using both in vitro and in vivo conditions. In the Th1 skewed condition, BV increased the expression of IFN-γ mRNA and enhanced the expression of T-bet on purified CD4+ T cells from splenocytes of BALB/c mice. On the other hand, BV treatment did not alter the expression of IL-4 or GATA-3 in a Th2 driven environment. To elucidate the effects of BV on Th1/Th2 lineage development under in vivo conditions, BV was given by intraperitonial injection to BALB/c mice. It significantly increased the CD4+ T cell population and enhanced IFN-γ expression, while IL-4 transcripts were not altered upon in vivo activation using an anti-CD3 antibody injection. Taken together, these results imply that BV induces Th1 lineage development from CD4+ T cells by increasing the expression of a Th1-specific cytokine, IFN-γ. In addition, this result may be mediated by inducing a Th1-specific transcription factor, T-bet.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 5, Issue 9, August 2005, Pages 1406-1414
Journal: International Immunopharmacology - Volume 5, Issue 9, August 2005, Pages 1406-1414
نویسندگان
Sangsoo Nam, Eunjung Ko, Seong-kyu Park, Seonggyu Ko, Chan-yong Jun, Min-Kyu Shin, Moo-Chang Hong, Hyunsu Bae,