کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9008094 | 1122736 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells](/preview/png/9008094.png)
چکیده انگلیسی
Polysialic acid (PSA) is a dynamically regulated carbohydrate modification of the neural cell adhesion molecule NCAM, which has been linked to cancer development and dissemination. Two enzymes, the polysialyltransferases ST8SiaIV and ST8SiaII, are known to be involved in the polysialylation of NCAM. The antiepileptic drug valproic acid (VPA) is associated with anti-cancer activity. In this study, VPA blocked the adhesion of several neuroectodermal tumor cell lines to human umbilical vein endothelial cells. Furthermore, VPA induced intracellular PSA accumulation and enhanced expression of PSA-NCAM on the cell surface. Using a semiquantitative RT-PCR strategy, VPA was shown to up-regulate ST8SiaIV mRNA, whereas ST8SiaII mRNA was down-regulated by this compound. Our data indicate that increased expression of ST8SiaIV enables accelerated polysialylation of NCAM, which might be coupled to a loss of adhesive functions of tumor cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 5, Issue 4, April 2005, Pages 757-769
Journal: International Immunopharmacology - Volume 5, Issue 4, April 2005, Pages 757-769
نویسندگان
Wolf-Dietrich Beecken, Tobias Engl, Henry Ogbomo, Borna Relja, Jindrich Cinatl, Jürgen Bereiter-Hahn, Elsie Oppermann, Dietger Jonas, Roman A. Blaheta,