کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9009681 | 1560414 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anti-ulcerogenic activity of xanthanolide sesquiterpenes from Xanthium cavanillesii in rats
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Anti-ulcerogenic activity of xanthanolide sesquiterpenes from Xanthium cavanillesii in rats Anti-ulcerogenic activity of xanthanolide sesquiterpenes from Xanthium cavanillesii in rats](/preview/png/9009681.png)
چکیده انگلیسی
The preventive effect of natural xanthanolides as well as a series of synthetic derivatives on ulcer formation induced by absolute ethanol in rats was examined. Among the compounds tested, xanthatin gave the strongest protective activity. The inhibitory action exerted by this molecule on the lesions induced by 0.6N HCl and 0.2N NaOH was highly significant, reducing ulceration in the range of 58-96% at a dose from 12.5 to 100 mg/kg. These results appear to confirm that the presence of a non-hindered α,β-unsaturated carbonyl group seems to be an essential structural requirement for the gastric cytoprotective activity of these compounds. In order to explore this possibility, a theoretical conformational analysis was performed. We suggest that the mechanism of protection would involve, at least in part, a nucleophylic attack of the sulfhydryl group from the biological molecules present in the gastric mucosa to electrophylic carbons accessible in suitable Michael acceptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 100, Issue 3, 14 September 2005, Pages 260-267
Journal: Journal of Ethnopharmacology - Volume 100, Issue 3, 14 September 2005, Pages 260-267
نویسندگان
Laura S. Favier, Alejandra O.M. MarÃa, Graciela H. Wendel, Eduardo J. Borkowski, Oscar S. Giordano, Lilian Pelzer, Carlos E. Tonn,