کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9009706 | 1124076 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Allophylus serratus: A plant with potential anti-ulcerogenic activity
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Allophylus serratus is known to possess various therapeutic properties. We evaluated the anti-ulcerogenic property of crude ethanolic extract of Allophylus serratus (AS) in different ulcer models in Sprague-Dawley rats. The extract at 400Â mg/kg body weight, once daily, orally has a significant effect in cold restraint (CRU, 2Â h cold restraint stress), aspirin (ASA, 150Â mg/kg body weight, orally), alcohol (AL, 1Â ml/200Â gm of absolute alcohol) and pyloric ligation (PL, 4Â h ligation) induced gastric ulcer models as it showed protection index of 71.28, 62.50, 90.84 and 64.29% protection, respectively whereas, standard drug omeprazole (OMZ, 10Â mg/kg body weight) has shown protection index of 85.70, 74.99 and 74.99 in CRU, ASA and PL model respectively. Sucralfate (SUC, 500Â mg/kg body weight) as a standard drug in AL model has 93.20% protection. Furthermore, AS has significantly decreased the free acidity (72.41%), total acidity (47.97%) and peptic activity (24.59%), respectively as well as has significantly increased the mucus secretion (29.41%). Conclusively the ulcer protective effect of AS may be due to its anti-secretory along with cytoprotective mechanism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 99, Issue 3, 14 July 2005, Pages 361-366
Journal: Journal of Ethnopharmacology - Volume 99, Issue 3, 14 July 2005, Pages 361-366
نویسندگان
Poonam Dharmani, Pushpesh Kumar Mishra, Rakesh Maurya, Vinay Singh Chauhan, Gautam Palit,