کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9009771 1124084 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rats and mice
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rats and mice
چکیده انگلیسی
The present study evaluated the neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rodents. Effects on the spontaneous motor activity (SMA), exploratory behaviour, pentobarbital sleeping time, apomorphine-induced stereotypic behaviour and motor coordination (rota-rod performance) were investigated. The extract (50-200 mg/kg p.o.) significantly (P < 0.05) decreased the SMA and exploratory behaviour in mice and prolonged pentobarbital sleeping time in rats dose-dependently. The extract also remarkably attenuated the intensity of apomorphine-induced stereotypy dose-dependently in mice, but had no effect on motor coordination as determined by the performance on rota-rod. These results indicate the presence of psychoactive substances in the aqueous extract of the root bark of Nauclea latifolia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 97, Issue 1, 10 February 2005, Pages 53-57
نویسندگان
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