کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9009839 1124087 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Kurarinone isolated from Sophora flavescens Ait inhibited MCP-1-induced chemotaxis
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Kurarinone isolated from Sophora flavescens Ait inhibited MCP-1-induced chemotaxis
چکیده انگلیسی
The accumulation of circulating monocytes in the arterial wall is an early in atherosclerotic plaque formation. Monocyte chemoattractant protein-1 (MCP-1) promotes the migration of monocytes and would play a role in the development of atherosclerotic lesions. Searching for inhibitors of MCP-1-induced cell migration from natural sources, we isolated one active compound through active-guided fractionations from the MeOH extracts of Sophora flavescens Ait (Leguminosae). On the basis of spectral evidence, the structure of active compound was identified as kurarinone. It inhibited the migration of THP-1 cells induced by MCP-1 with IC50 value of 19.2 μg/mL. In addition, it inhibited the binding of MCP-1 to THP-1 cells and phosphorylation of p42/44 MARK.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 97, Issue 3, 21 March 2005, Pages 515-519
نویسندگان
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