کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9009946 | 1560417 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antioxidant effect of Inonotus obliquus
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کلمات کلیدی
DPPHDcfAAPHDPBSNBTInonotus obliquus2,2′-azobis(2-amidinopropane)dihydrochloride1,1-diphenyl-2-picrylhydrazyl - 1،1-دیفنیل-2-پریکیل هیدرازیل3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide - 3- (4،5-dimethylthiazol-2-yl) -2،5-difenyl tetrazolium bromideMTT - MTTHydrogen peroxide - آب اکسیژنهAntioxidant - آنتی اکسیدانnitroblue tetrazolium chloride - تترازولیم کلرید nitroblueDulbecco's phosphate-buffered saline - فسفات باسیل نمک Dulbecco
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Antioxidant effect of Inonotus obliquus Antioxidant effect of Inonotus obliquus](/preview/png/9009946.png)
چکیده انگلیسی
The mushroom Inonotus obliquus (Fr.) Pilát (Hymenochaetaceae), has been widely used as a folk medicine in Russia, Poland and most of the Baltic countries. The purpose of this study was to elucidate the antioxidant capacities of Inonotus obliquus. Four extracts from the fungus were evaluated for antioxidant activity against the 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide, and peroxyl radicals. The polyphenolic extract had a strong antioxidant activity, and the extract containing triterpenoids and steroids presented a relatively strong antioxidant effect. The polysaccharide extract, however, was inactive. The protective effects of these four extracts were assessed against hydrogen peroxide-induced oxidative stress using a human keratinocyte cell line, HaCaT. Our results show that the polyphenolic extract protected these cells against hydrogen peroxide-induced oxidative stress, while the polysaccharide, triterpenoid and steroid extracts were ineffective. Additionally, the remnant polyphenolic and low molecular weight polysaccharide extracts showed a weakly protective effect at a concentration of 50 μg/ml. Our results indicate that Inonotus obliquus has the capacity to scavenge free radicals at concentrations higher than 5 μg/ml and that the polyphenolic extract can protect cells against oxidative stress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 96, Issues 1â2, 4 January 2005, Pages 79-85
Journal: Journal of Ethnopharmacology - Volume 96, Issues 1â2, 4 January 2005, Pages 79-85
نویسندگان
Yong Cui, Dong-Seok Kim, Kyoung-Chan Park,