کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9009960 1560417 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The inhibition of gastric mucosal injury by Punicagranatum L. (pomegranate) methanolic extract
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
The inhibition of gastric mucosal injury by Punicagranatum L. (pomegranate) methanolic extract
چکیده انگلیسی
Administration of 70% methanolic extract of Punicagranatum fruit rind (250 mg/kg and 500 mg/kg) shows a percentage of inhibition in 22.37, 74.21 and 21.95, 63.41 in aspirin- and ethanol-induced gastric ulceration, respectively. In treated groups of animals, the in vivo antioxidant levels such as superoxide dismutase (SOD), catalase, glutathione (GSH) and glutathione peroxidase (GPx) levels were increased and found more or less equal to the normal values. The tissue lipid peroxidation level was found to be decreasing in treated groups of animals as compared to the control group. The histopathological examination of the stomach of the ulcerated animals shows severe erosion of gastric mucosa, sub-mucosal edema and neutrophil infiltration. All of these symptoms were found to be normal in treated groups. In general, the results of the present investigation revealed the gastroprotective activity of the extract through antioxidant mechanism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 96, Issues 1–2, 4 January 2005, Pages 171-176
نویسندگان
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