کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9010228 | 1124104 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Herb-drug interaction of Evodia rutaecarpa extract on the pharmacokinetics of theophylline in rats
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The extract of Evodia rutaecarpa fruit and its preparation were used for the treatment of gastrointestinal disorders and headache. To assess the possible herb-drug interaction, the ethanol extract of Evodia rutaecarpa fruit (1 and 2Â g/kg/day, p.o.) and the herbal preparation Wu-Chu-Yu-Tang (1 and 5Â g/kg/day) were given to rats daily for three consecutive days and on the fourth day theophylline was administered (2Â mg/kg, i.v.). Theophylline concentration in blood was measured by a microdialysis coupled to a liquid chromatographic system. Pharmacokinetic data were calculated by noncompartmental model. The results indicate that the theophylline level was significantly decreased by the pretreatment with the extract of Evodia rutaecarpa and herbal preparation Wu-Chu-Yu-Tang with dose-related manner. It is suggested that the herb-drug interaction may occur through the induction of the metabolism of theophylline.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 102, Issue 3, 1 December 2005, Pages 440-445
Journal: Journal of Ethnopharmacology - Volume 102, Issue 3, 1 December 2005, Pages 440-445
نویسندگان
Woan-Ching Jan, Lie-Chwen Lin, Chieh-Fu-Chen Chieh-Fu-Chen, Tung-Hu Tsai,