کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9010232 | 1124104 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antibacterial, anti-inflammatory, anti-cholinesterase and mutagenic effects of extracts obtained from some trees used in South African traditional medicine
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Mueller–Hinton agar5,5-dithiobis-2-nitrobenzoic acidMICTLCintDTNBATCIBSA - BSAbovine serum albumin - آلبومین سرم گاوAChE - آهیAcetylthiocholine iodide - اتیل تیوکولین یدیدAcetylcholinesterase - استیل کولین استرازMinimum inhibitory concentration - حداقل غلظت مهاریGenotoxicity - سمیت ژنتیکیAnti-inflammatory activity - فعالیت ضد التهابیAntibacterial activity - فعالیت ضد باکتریAcetylcholinesterase inhibitory activity - فعالیت مهار کننده استیل کولین استرازthin layer chromatography - کروماتوگرافی لایه نازک
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Extracts obtained from 10 trees used in South African traditional medicine were screened for antibacterial, anti-inflammatory (COX-1 and COX-2) and anti-cholinesterase activities and investigated for potential mutagenic effects using the Ames test. Antibacterial activity was detected using the disc-diffusion and micro-dilution assays. The extracts were tested against Gram-positive bacteria: Bacillus subtilis, Staphylococcus aureus, Micrococcus luteus and Gram-negative bacteria: Escherichia coli and Klebsiella pneumoniae. Of the 78 different plant extracts investigated, 80% showed activity against both Gram-positive and Gram-negative bacteria in the disc-diffusion assay. In the micro-dilution assay, 60% of the plant extracts showed minimum inhibitory concentration (MIC) values â¤1.56 mg mlâ1. The lowest MIC value (0.092 mg mlâ1) was recorded for an ethyl acetate root extract of Acacia sieberiana against Staphylococcus aureus and Escherichia coli. In the anti-inflammatory assay, 70% of the investigated plant extracts (0.25 mg mlâ1) inhibited both COX-1 and COX-2 activity (>50% and 70% for water and organic solvent extracts, respectively). An ethyl acetate leaf extract of Trichilia dregeana showed selective inhibition of COX-2 (81%). In the acetylcholinesterase inhibitory test, 21% of the plant extracts were active at a concentration â¤1 mg mlâ1 using the micro-dilution assay. The lowest IC50 value was 0.04 mg mlâ1 obtained with an ethanol bark extract of Combretum kraussii. None of the investigated plants showed any potential mutagenic effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 102, Issue 3, 1 December 2005, Pages 457-464
Journal: Journal of Ethnopharmacology - Volume 102, Issue 3, 1 December 2005, Pages 457-464
نویسندگان
I.M.S. Eldeen, E.E. Elgorashi, J. van Staden,