کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9010397 | 1124109 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phytochemical and pharmacological study of Sedum dendroideum leaf juice
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The fresh juice from leaves of Sedum dendroideum Moc & Sessé (Crassulaceae) is used in Brazilian traditional medicine for the treatment of gastric and inflammatory disorders. The present investigation was carried out to evaluate in vivo antinociceptive and anti-inflammatory activities of this plant material. The oral administration (0.1-1Â g/kg) of the lyophilized Sedum dendroideum juice (LJ) caused a significant dose-related reduction of acetic acid-induced writhing response (ID50Â =Â 631Â mg/kg) and inhibited croton oil-induced ear oedema formation (66% inhibition at 1Â g/kg) in mice. In the formalin-induced nociception in mice, LJ (1Â g/kg) only inhibited the second phase of nociception (46%). Phytochemical investigation revealed four known kaempferol glycosides, here, described at the first time for this species. These flavonoids probably explain the antinociceptive and anti-inflammatory effects of the fresh juice of Sedum dendroideum.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 102, Issue 2, 14 November 2005, Pages 217-220
Journal: Journal of Ethnopharmacology - Volume 102, Issue 2, 14 November 2005, Pages 217-220
نویسندگان
Giany O. De Melo, David do C. Malvar, Frederico A. Vanderlinde, Priscilla A. Pires, Wellington S. Côrtes, Pedro Germano Filho, Michelle F. Muzitano, Carlos R. Kaiser, Sônia S. Costa,