کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9010552 | 1560415 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antihemorrhagic, antinucleolytic and other antiophidian properties of the aqueous extract from Pentaclethra macroloba
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کلمات کلیدی
PBSCDTBothrops jararacussu venomBALTAntihemorrhagicBASPSnake venoms - زهر مارBothrops jararaca venom - سموم Bothros jararacaCrotalus durissus terrificus venom - سموم Crotalus durissus terrificusBothrops asper venom - سموم گوجه فرنگیPhosphate buffered saline - فسفات بافر شورBothrops - هر دوCreatine kinase - کراتین کیناز
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Several Brazilian plants have been utilized in folk medicine as active agents against various effects induced by snake venoms. The inhabitants of the Amazon region use, among others, the macerated bark of a plant popularly named “Pracaxi” (Pentaclethra macroloba Willd) to combat these effects. We report now the antihemorrhagic properties against snake venoms of the aqueous extract of Pentaclethra macroloba (EPema). EPema exhibited full inhibition of hemorrhagic and nucleolytic activities induced by several snake venoms. Additionally, partial inhibition of myotoxic, lethal, phospholipase and edema activities of snake venoms and its isolated PLA2s by EPema is reported. In vivo tests showed that EPema is able to totally inhibit a Bothrops jararacussu metalloprotease (BjussuMP-I) induced hemorrhage, suggesting interaction of the extract compounds with this high molecular weight protein. The extract did induce neither hemorrhage nor death in mice when administered alone by i.m. route. When administered separately by i.m. route, the extract did not induce death in mice at 12.5-300Â mg/kg doses. Other assays demonstrated that EPema was unable to inhibit fibrinogenolytic and coagulant activities of Bothrops atrox venom. Although the mechanism of action of EPema is still unknown, the finding that no visible change was detected in the electrophoretic pattern of snake venom after incubation with the extract excludes proteolytic degradation as a potential mechanism. The search for new inhibitors of venom metalloproteases and DNAases are a relevant task. Investigation of snake venom inhibitors can provide useful tools for the elucidation of the action mechanisms of purified toxins. Furthermore, these inhibitors can be used as molecular models for development of new therapeutical agents in the treatment of ophidian accidents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 100, Issues 1â2, 22 August 2005, Pages 145-152
Journal: Journal of Ethnopharmacology - Volume 100, Issues 1â2, 22 August 2005, Pages 145-152
نویسندگان
Jocivânia O. da Silva, Juliana S. Coppede, Vanessa C. Fernandes, Carolina D. Sant'Ana, Fábio K. Ticli, MaurÃcio V. Mazzi, José R. Giglio, Paulo S. Pereira, Andreimar M. Soares, Suely V. Sampaio,