کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9011442 | 1124156 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hypotensive effect of the hydroalcoholic extract from Jacaranda mimosaefolia leaves in rats
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hypothermic and cardiovascular activities of the methanol extract of Jacaranda mimosaefolia leaves were tested. To evaluate the hypotensive properties, anesthetized rats were used and temperature, blood pressure, and cardiac frequency were recorded. In addition, the in vitro effect produced by the extract on induced contraction with norepinephrine (NE) in rat aorta rings was evaluated. The extract produced a significant hypothermic effect with a maximum at 2Â h, an effect which was accompanied by hypotension and low cardiac frequency, physiological conditions that were again re-established to the following 2Â h. In isolated aorta preparations norepinephrine antagonistic effect was not correlated with the presence of Ca2+, pD2 for NE was modified by the extract, an effect that could explain a blockade of the adrenergic receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 97, Issue 2, 28 February 2005, Pages 301-304
Journal: Journal of Ethnopharmacology - Volume 97, Issue 2, 28 February 2005, Pages 301-304
نویسندگان
Pilar Nicasio, Mariana Meckes,