کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9030223 | 1130726 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reduction in functional potency of the neurotoxin domoic acid in the presence of cadmium and zinc ions
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Reduction in functional potency of the neurotoxin domoic acid in the presence of cadmium and zinc ions Reduction in functional potency of the neurotoxin domoic acid in the presence of cadmium and zinc ions](/preview/png/9030223.png)
چکیده انگلیسی
The tricarboxylic neurotoxin domoic acid (DA) binds trace metals such as iron and copper. In vitro brain slice recording (area CA1 of rat hippocampal slices) was used to assess changes in DA potency in the presence of cadmium and zinc. Cadmium or zinc alone had little or no effect on CA1 responses. DA alone produced hyperexcitability and, with prolonged administration, a robust suppression of CA1 responses. Coadministration of DA with either 2 or 4 μM Cd2+ produced significant reductions in the potency of DA; less striking effects were seen in the presence of 4 μM Zn2+. These findings suggest that interactions of Cd2+ and Zn2+ with DA result in the formation of trace metal-neurotoxin complexes which are either unavailable for binding to ionotropic glutamate receptors, or bind without producing full agonist activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 20, Issue 1, July 2005, Pages 175-181
Journal: Environmental Toxicology and Pharmacology - Volume 20, Issue 1, July 2005, Pages 175-181
نویسندگان
José R. Hoedemaker, Barrie M. Peake, D. Steven Kerr,