کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9030316 | 1130734 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PCB profiles in mouse skin biopsies and fat from an environmental mixture
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کلمات کلیدی
TEFAHRTEQCyPPCBsPCDFsPCDDsPolychlorinated dibenzofurans - dibenzofurans پلی کربناتGC–MS - GC-MSPCA - PCAAccumulation - انباشتPolychlorinated biphenyls - بیفنیل پلیکلر Redistribution - توزیع مجددElimination - حذفPolychlorinated dibenzo-p-dioxins - دی بنزوپروتئینهای پلی کربناتSARS - سارسcytochrome P-450 - سیتوکروم P-450Skin - پوستFat - چربیGas chromatography - کروماتوگرافی گازیaryl hydrocarbon receptor - گیرنده آرویل هیدروکربن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Fat, ear skin and trunk skin were collected from mice exposed to PCB-contaminated soil for PCB specific congener analysis. The soil had been retrieved from a Superfund site prior to remediation. Mice were exposed to either contaminated soil or control soil for 4 weeks. Skin samples were collected immediately after the 4-week exposure and again after 4-week recovery. Out of 141 PCB congeners measured, only 91 peaks representing 103 congeners were above quantification limits. Relative liver weights in PCB-exposed mice doubled indicating significant enzyme induction. Consistent with this observation, total PCB residues declined about 80% during the 4-week recovery. The PCB residue profiles in the ear skin (208Â mg/kg total) and trunk skin (129Â mg/kg) after 4-week exposure were identical and similar to those in body fat (370Â mg/kg) and in the contaminated soil. The results confirmed that both skin tissues are important reservoirs and can serve as useful biopsy media.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 19, Issue 1, January 2005, Pages 71-84
Journal: Environmental Toxicology and Pharmacology - Volume 19, Issue 1, January 2005, Pages 71-84
نویسندگان
Kanjana Imsilp, Larry Hansen,