کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9030856 | 1130954 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro
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کلمات کلیدی
MTT, 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromideAAPHTBARS, 2-thiobarbituric acid reactive substancesPalmaria palmataAMVNAMVN, 2,2′-azobis(2,4-dimethylvaleronitrile)BHA, butylated hydroxyanisole - BHA، هیدروکسی آنیزول butyllatedEGC, epigallocatechin - EGC، epigallocatechinFBS, foetal bovine serum - FBS، سرم جنین گاوMDA, malondialdehyde - MDA، مالون دی آلدئیدMEM, minimum essential medium - MEM، حداقل حداقل لازم استOH, hydroxyl radical - OH، هیدروکسیل رادیکالROS, Reactive Oxygen Species - ROS، انواع اکسیژن واکنشیTCA, trichloroacetic acid - TCA، اسید تری کلرواستیکLipid oxidation - اکسیداسیون لیپیدیCell proliferation - تکثیر سلولیDulse - دالسHeLa cells - سلول های هلاCD, conjugated dienes - سی دی، دیون های کنجدAntioxidant activity - فعالیت آنتیاکسیدانیPBS, phosphate buffered saline - محلول نمکِ فسفات با خاصیت بافریGSH, glutathione - گلوتاتیون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro](/preview/png/9030856.png)
چکیده انگلیسی
Previously, we reported that a 1-butanol soluble extract of the edible red alga Palmaria palmata, known as dulse, exhibited hydroxyl and stable free radical scavenging activity as well as inhibition of lipid peroxidation, attributed to the reducing activity and polyphenol content of the dulse extract. In the present study, we evaluated the antioxidant and antiproliferative activities of two grades of dulse harvested from Canadian Maritime locations differing in UV radiation exposure (i.e. west versus east coasts of Grand Manan Island, New Brunswick). The 1-butanol soluble extract from Grade 1 dulse (reduced UV-exposure) exhibited lower reducing activity versus Grade 2 dulse (greater UV exposure) reflecting a lower requirement for endogenous antioxidant protection. Grade 1 and 2 dulse extracts both inhibited (p ⩽ 0.03) AAPH-induced lipid peroxidation, but had no effect on AMVN-induced lipid peroxidation, demonstrating the aqueous nature of the antioxidants involved. The Grade 1 and 2 dulse extract inhibition (p < 0.05) of HeLa cell proliferation was dose-dependent over 0.5-5.0 mg/mL and maximal at 48 and 72 h incubation. The antiproliferative effects of the Grade 1 and 2 dulse extracts in the present study likely reflect the bioactivity of the polyphenol content of these extracts.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 43, Issue 7, July 2005, Pages 1073-1081
Journal: Food and Chemical Toxicology - Volume 43, Issue 7, July 2005, Pages 1073-1081
نویسندگان
Yvonne V. Yuan, Meshell F. Carrington, Natalie A. Walsh,