کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9030860 | 1130954 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An approach to investigating the importance of high potency polycyclic aromatic hydrocarbons (PAHs) in the induction of lung cancer by air pollution
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کلمات کلیدی
DNA adducts1-OHP, 1-hydroxypyreneB[a]P, benzo[a]pyrene - B [a] P، benzo [a] پورنETS, Environmental tobacco smoke - ETS، دود سیگار محیطیPAHs, polycyclic aromatic hydrocarbons - PAHs، هیدروکربن های چند حلقه ای معطرPBLs, peripheral blood lymphocytes - PBLs، لنفوسیت های خون محیطیELISA, enzyme-linked immunosorbent assay - تست الیزاCarcinogenicity - سرطان زاییMS, mass spectrometry - طیفسنجی جرمیPolycyclic aromatic hydrocarbons - هیدروکربن آروماتیک چندحلقهای
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Evidence suggests that people living in urban areas have an increased risk of lung cancer due to higher levels of air pollution in these areas. Benzo[a]pyrene (B[a]P) is currently used as the main indicator of carcinogenic polycyclic aromatic hydrocarbons (PAHs) in air pollution, but there is concern that B[a]P may not be the ideal surrogate of choice for PAH mixtures since higher potency PAHs have recently been identified which could potentially contribute more and variably to the overall carcinogenicity. Dibenzo[a, h]anthracene (DBA) and dibenzo[a, l]pyrene (DB[a, l]P) are estimated to have carcinogenic potencies 10 or more times greater than B[a]P but data on their presence and formation in the environment are limited. Several occupational and environmental PAH biomonitoring studies are reviewed here, with particular focus on the specific exposure groups, study design, sample tissue, in particular the use of nasal tissues, and biomarkers used in each study. Consideration of these data is then used to propose a novel biomonitoring approach to evaluate exposure, uptake and the role of high potency PAHs in air pollution-related lung cancer. This is based upon an occupational study examining specific DNA adducts for DBA and DB[a, l]P in nasal cells to evaluate the extent to which these high potency PAHs might contribute to the increased risk of developing lung cancer from air pollution.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 43, Issue 7, July 2005, Pages 1103-1116
Journal: Food and Chemical Toxicology - Volume 43, Issue 7, July 2005, Pages 1103-1116
نویسندگان
K.B. Okona-Mensah, J. Battershill, A. Boobis, R. Fielder,